Insignia is a project to create and store information about a broad range
of microbial pathogens, focusing primarily on bacteria and viruses. Click on Run Insignia to perform a search, or check the Examples Page to see a short walkthrough of the system. There are two major components to the system:
- Insignia: A computational pipeline to generate unique DNA signatures for any and all pathogens in our database
- Gemina: An integrated database containing genome sequences, phenotypic information, and comparative genomic analysis of all pathogens
For citation, more information, or validation results for Vibrio cholerae, please see our publications:
DNA Signature Discovery and Validation. Phillippy
AM, Mason JA, Ayanbule K, Sommer DD, Taviani E, Huq
A, Colwell RR, Knight IT, Salzberg SL. PLoS Comput
Biol. 2007 May 18;3(5):e98.
Insignia: a DNA signature search web server for diagnostic assay development. Phillippy
AM, Ayanbule K, Edwards NJ, Salzberg SL. Nucleic Acids Res. 2009 May 5; doi: 10.1093/nar/gkp286.
- Organisms in Insignia -
There are 13928 organisms in Insignia (11274 viruses/phages ,2653 non-viruses)
List of organisms currently in database:
Insignia is funded by the Homeland Security Advanced Research
Projects Agency (HSARPA) at the Department of Homeland Security.